Article

CRISPR-based epigenome and genome editing reveal novel roles for PLEC in cartilage biology, mechanobiology, and response to inflammation

2026-08-18

Abstract excerpt

<title>Abstract</title> <bold>Background</bold> Osteoarthritis (OA)-associated single nucleotide polymorphism (SNP) rs11780978 has previously been associated with differential methylation at sites within <italic>PLEC</italic> gene and differential expression of <italic>PLEC</italic> in multiple joint tissues, including cartilage. We undertook experiments to identify novel differential methylation sites...

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Literature Corpus work: 0c7547c4-ac93-5f6b-a484-fb6a916e9034
DOI: 10.21203/rs.3.rs-10171592/v1

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