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Article

Mechanoepigenetics in musculoskeletal disease.

Osteoarthritis and cartilage - 1 Mar 2026

Coveney Clarissa R, Capellini Terence D

Abstract excerpt

This review explores the intricate interplay between genetic variants, mechanical forces, and the epigenetic landscape (defined as 'mechanoepigenetics'), particularly in the context of musculoskeletal (MSK) diseases such as osteoarthritis. Whilst our understanding of Mendelian monogenic disease has progressed with exome sequencing and the generation of novel gene therapies, common complex diseases characterized...

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Identifiers

PMID: 40480604
DOI: 10.1016/j.joca.2025.05.012
PMCID: PMC12258969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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