Article

Preservation and Clonal Behavior of Extrachromosomal DNA in Patient-Derived Xenograft Models of Childhood Cancers

2025-08-19

Abstract excerpt

Extrachromosomal DNA (ecDNA) is a powerful oncogenic driver linked to poor prognosis in pediatric cancers. Whole-genome sequencing of 338 patient-derived xenograft (PDX) samples and 127 matched primary tumors across multiple childhood cancer types was used to compare ecDNA prevalence, sequence conservation, and clonal dynamics. ecDNA in PDX models frequently mirrored oncogene amplifications observed in patient tum...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f077f594-c317-5fa1-97d1-ee26be62b8cb
DOI: 10.1101/2025.08.14.670153

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Preservation and Clonal Behavior of Extrachromosomal DNA in Patient-Derived Xenograft Models of Childhood CancersDOI 10.1101/2025.08.14.670153Read

Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumorsSemantic proximity Read

Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversitySemantic proximity Read

Extensive Clonal Branching Shapes the Evolutionary History of High-Risk Pediatric CancersSemantic proximity Read

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma.Semantic proximity Read

Extrachromosomal DNA–Driven Oncogene Spatial Heterogeneity and Evolution in GlioblastomaSemantic proximity Read

Genomic profiling of childhood tumor patient-derived xenograft models to enable rational clinical trial designSemantic proximity Read

Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversitySemantic proximity Read

Extrachromosomal DNA: shaping the evolutionary dynamics of cancer.Semantic proximity Read

Genomic profiling of circulating tumor DNA for childhood cancers.Semantic proximity Read

EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAsSemantic proximity Read

Patient-derived xenografts undergo murine-specific tumor evolutionSemantic proximity Read

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastomaSemantic proximity Read