Article

Intercellular extrachromosomal DNA copy number heterogeneity drives cancer cell state diversity

2023-01-21

Abstract excerpt

Neuroblastoma is characterised by extensive inter- and intra-tumour genetic heterogeneity and varying clinical outcomes. One possible driver for this heterogeneity are extrachromosomal DNAs (ecDNA), which segregate independently to the daughter cells during cell division and can lead to rapid amplification of oncogenes. While ecDNA-mediated oncogene amplification has been shown to be associated with poor prognosis...

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Literature Corpus work: aad7c9a0-6966-501b-b1db-c3dca93a8def
DOI: 10.1101/2023.01.21.525014

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