Article
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma.
Nature genetics - 1 May 2018
deCarvalho Ana C, Kim Hoon, Poisson Laila M, Winn Mary E, Mueller Claudius, Cherba David, Koeman Julie, Seth Sahil, Protopopov Alexei, Felicella Michelle, Zheng Siyuan, Multani Asha, Jiang Yongying, Zhang Jianhua, Nam Do-Hyun, Petricoin Emanuel F, Chin Lynda, Mikkelsen Tom, Verhaak Roel G W
Abstract excerpt
To understand how genomic heterogeneity of glioblastoma (GBM) contributes to poor therapy response, we performed DNA and RNA sequencing on GBM samples and the neurospheres and orthotopic xenograft models derived from them. We used the resulting dataset to show that somatic driver alterations including single-nucleotide variants, focal DNA alterations and oncogene amplification on extrachromosomal DNA (ecDNA)...
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