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Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors

2025-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Circular extrachromosomal DNA (ecDNA) is a powerful driver of oncogene amplification and tumor evolution, yet its prevalence, composition, and clinical significance across pediatric cancers remains incompletely understood. Leveraging two major cloud-based genomic data repositories, we analyzed whole genome sequencing data from 3,630 tumor biosamples representing 2,967 children across 39 solid tu...

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Literature Corpus work
7e4407e0-d5d4-59c9-9dac-9d592af5e777
DOI
10.1101/2025.07.22.24308163
Open publication

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Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumorsDOI 10.1101/2025.07.22.24308163
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