Article

Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma

2016-10-14

Abstract excerpt

<h4>ABSTRACT</h4> To understand how genomic heterogeneity of glioblastoma (GBM) contributes to the poor response to therapy, which is characteristic of this disease, we performed DNA and RNA sequencing on GBM tumor samples and the neurospheres and orthotopic xenograft models derived from them. We used the resulting data set to show that somatic driver alterations including single nucleotide variants, focal DNA al...

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Literature Corpus work: cf36bb26-6bdb-55aa-8771-c45aebd87a4d
DOI: 10.1101/081158

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