Article
EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs
2025-04-03
Abstract excerpt
<h4>Summary</h4> Extrachromosomal DNA (ecDNA) amplifications are prevalent drivers of human cancers. We show that ecDNAs exhibit elevated structural variants leading to gene fusions that produce oncogene fusion transcripts. The long noncoding RNA (lncRNA) gene PVT1 is the most recurrent structural variant across cancer genomes, with PVT1-MYC fusions arising most frequently on ecDNA. PVT1 exon 1 is the predomin...
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Identifiers and source
- Literature Corpus work
- 59e4b46f-28cc-59bd-a47f-615adede0625
- DOI
- 10.1101/2025.04.01.646515