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Article

Extensive Clonal Branching Shapes the Evolutionary History of High-Risk Pediatric Cancers

10 Feb 2020

Abstract excerpt

Abstract Darwinian evolution of tumor cells remains underexplored in childhood cancer. We here reconstruct the evolutionary histories of 56 pediatric primary tumors, including 24 neuroblastomas, 24 Wilms tumors, and 8 rhabdomyosarcomas. Whole-genome copy-number and whole-exome mutational profiling of multiple regions per tumor were performed, followed by clonal deconvolution to reconstruct a phylogenetic tree for...

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PMID: 32041836
DOI: 10.1158/0008-5472.can-19-3468

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