Article
Genomic profiling of circulating tumor DNA for childhood cancers.
Leukemia - 1 Feb 2025
Lei Shaohua, Jia Sujuan, Takalkar Sunitha, Chang Ti-Cheng, Ma Xiaotu, Szlachta Karol, Xu Ke, Cheng Zhongshan, Hui Yawei, Koo Selene C, Mead Paul E, Gao Qingsong, Kumar Priyadarshini, Bailey Colin P, Sunny Jobin, Pappo Alberto S, Federico Sara M, Robinson Giles W, Gajjar Amar, Rubnitz Jeffrey E, Jeha Sima, Pui Ching-Hon, Inaba Hiroto, Wu Gang, Klco Jeffery M, Tatevossian Ruth G, Mullighan Charles G
Abstract excerpt
The utility of circulating tumor DNA (ctDNA) analysis has not been well-established for disease detection and monitoring of childhood cancers, especially leukemias. We developed PeCan-Seq, a deep sequencing method targeting diverse somatic genomic variants in cell-free samples in childhood cancer. Plasma samples were collected at diagnosis from 233 children with hematologic, solid and brain tumors. All children...
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