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Intercellular extrachromosomal DNA copy-number heterogeneity drives neuroblastoma cell state diversity

1 Sept 2024

Abstract excerpt

Neuroblastoma exhibits significant inter- and intra-tumor genetic heterogeneity and varying clinical outcomes. Extrachromosomal DNAs (ecDNAs) may drive this heterogeneity by independently segregating during cell division, leading to rapid oncogene amplification. While ecDNA-mediated oncogene amplification is linked to poor prognosis in various cancers, the effects of ecDNA copy-number heterogeneity on...

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PMID: 39255063
DOI: 10.1016/j.celrep.2024.114711

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