Article

Genomic profiling of childhood tumor patient-derived xenograft models to enable rational clinical trial design

2019-03-06

Abstract excerpt

<h4>Summary</h4> Accelerating cures for children with cancer remains an immediate challenge due to extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Te...

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Literature Corpus work: 1254970a-6e92-5eea-936f-daf73907dfdd
DOI: 10.1101/566455

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