Article

Inter-subunit Crosstalk via PDZ Synergistically Governs Allosteric Activation of Proapoptotic HtrA2

2021-10-04

Abstract excerpt

<h4>SUMMARY</h4> Mitochondrial serine protease – High temperature requirement A2 (HtrA2), is associated with various diseases including neurodegenerative disorders and cancer. Despite availability of structural details, the reports on HtrA2’s mechanistic regulation that varies with the type of activation signals still remain non-concordant. To expound the role of regulatory PDZ domains in promoting synergistic co...

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Literature Corpus work: f06a058b-fd09-5741-ad30-11b8cc2bb261
DOI: 10.1101/2021.10.04.462974

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