Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progress in research on the role of Omi/HtrA2 in neurological diseases

6 Sept 2018

Abstract excerpt

Omi/HtrA2 is a serine protease present in the mitochondrial space. When stimulated by external signals, HtrA2 is released into the mitochondrial matrix where it regulates cell death through its interaction with apoptotic and autophagic signaling pathways. Omi/HtrA2 is closely related to the pathogenesis of neurological diseases, such as neurodegeneration and hypoxic ischemic brain damage. Here, we summarize the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cerebrovascular and genetic disorders
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30205651
DOI: 10.1515/revneuro-2018-0004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progress in research on the role of Omi/HtrA2 in neurological diseasesPMID 30205651Read ↗

The mitochondrial serine protease HtrA2/Omi: an overviewSemantic proximity Read ↗

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.Semantic proximity Read ↗

HtrA2/Omi is involved in 6-OHDA-induced endoplasmic reticulum stress in SH-SY5Y cells.Semantic proximity Read ↗

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagySemantic proximity Read ↗

Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.Semantic proximity Read ↗

Overview of Human HtrA Family Proteases and Their Distinctive Physiological Roles and Unique Involvement in Diseases, Especially Cancer and Pregnancy ComplicationsSemantic proximity Read ↗

HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.Semantic proximity Read ↗

HtrA Protease Family as Therapeutic TargetsSemantic proximity Read ↗

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.Semantic proximity Read ↗

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's diseaseSemantic proximity Read ↗

Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising targetSemantic proximity Read ↗

The mitochondrial protease HtrA2 restricts the NLRP3 and AIM2 inflammasomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.