Article
Genetic variability in the mitochondrial serine protease HTRA2 contributes to risk for Parkinson disease.
Human mutation - 1 Jun 2008
Bogaerts Veerle, Nuytemans Karen, Reumers Joke, Pals Philippe, Engelborghs Sebastiaan, Pickut Barbara, Corsmit Ellen, Peeters Karin, Schymkowitz Joost, De Deyn Peter Paul, Cras Patrick, Rousseau Frederic, Theuns Jessie, Van Broeckhoven Christine
Abstract excerpt
In one genetic study, the high temperature requirement A2 (HTRA2) mitochondrial protein has been associated with increased risk for sporadic Parkinson disease (PD). One missense mutation, p.Gly399Ser, in its C-terminal PDZ domain (from the initial letters of the postsynaptic density 95, PSD-95; d...
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