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Article

Structural basis of inactivation of human counterpart of mouse motor neuron degeneration 2 mutant in serine protease HtrA2.

Bioscience reports - 31 Oct 2018

Wagh Ajay R, Bose Kakoli

Abstract excerpt

Serine protease high temperature requirement protease A2 (HtrA2) is involved in apoptosis and protein quality control. However, one of its murine inactive mutants (S276C aka mnd2) is associated with motor neuron degeneration 2. Similarly, this conserved mutation in human HtrA2 (hHtrA2) also renders the protease inactive, implicating pathogenicity. However, the structural determinants for its inactivation have not...

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Identifiers

PMID: 30068699
DOI: 10.1042/BSR20181072
PMCID: PMC6172425

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