Article

Polymodal Allosteric Regulation of Type 1 Serine/Threonine Kinase Receptors via a Conserved Electrostatic Lock

2017-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Type 1 Serine/Threonine Kinase Receptors (STKR1) transduce a wide spectrum of biological signals mediated by TGF-β superfamily members. The STKR1 activity is tightly controlled by their regulatory glycine-serine rich (GS) domain adjacent to the kinase domain. Despite decades of studies, it remains unknown how physiological or pathological GS domain modifications are coupled to STKR1 kinase activ...

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Literature Corpus work: 1849ca19-f459-5563-8b52-bfa58cda3c9f
DOI: 10.1101/170837

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