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Article

Dissecting the role of interprotomer cooperativity in the activation of oligomeric high-temperature requirement A2 protein.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2021

Toyama Yuki, Harkness Robert W, Kay Lewis E

Abstract excerpt

The human high-temperature requirement A2 (HtrA2) mitochondrial protease is critical for cellular proteostasis, with mutations in this enzyme closely associated with the onset of neurodegenerative disorders. HtrA2 forms a homotrimeric structure, with each subunit composed of protease and PDZ (PSD-95, DLG, ZO-1) domains. Although we had previously shown that successive ligand binding occurs with increasing...

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Identifiers

PMID: 34446566
DOI: 10.1073/pnas.2111257118
PMCID: PMC8536338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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