Article

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

2023-03-09

Abstract excerpt

An increasing number of mutations associated with devastating human diseases are diagnosed by whole-genome/exon sequencing. Recurrent de novo missense mutations have been discovered in B56δ (encoded by PPP2R5D ), a regulatory subunit of protein phosphatase 2A (PP2A), that cause intellectual disabilities (ID), macrocephaly, Parkinsonism, and a broad range of neurological symptoms. Single-particle cryo-EM structur...

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Literature Corpus work: 24d9395d-ec98-5933-8585-44bfb5a4fa46
DOI: 10.1101/2023.03.09.530109

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