Article

Interplay of disordered and ordered regions of a human small heat shock protein yields an ensemble of “quasi-ordered” states

2019-08-29

Abstract excerpt

<h4>ABSTRACT</h4> Small heat shock proteins (sHPSs) are nature’s “first responders” to cellular stress, interacting with affected proteins to prevent their aggregation. Little is known about sHSP structure beyond its structured α-crystallin domain (ACD), which is flanked by disordered regions. In the human sHSP HSPB1, the disordered N-terminal region (NTR) represents nearly 50% of the sequence. Here, we present a...

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Literature Corpus work: 19072d70-0799-5a0a-9b2d-553d6e790627
DOI: 10.1101/750646

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