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Article

Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants.

PloS one - 1 Jan 2016

Gieldon Artur, Zurawa-Janicka Dorota, Jarzab Miroslaw, Wenta Tomasz, Golik Przemyslaw, Dubin Grzegorz, Lipinska Barbara, Ciarkowski Jerzy

Abstract excerpt

HtrA2(Omi) protease controls protein quality in mitochondria and plays a major role in apoptosis. Its HtrA2S306A mutant (with the catalytic serine routinely disabled for an X-ray study to avoid self-degradation) is a homotrimer whose subunits contain the serine protease domain (PD) and the regulatory PDZ domain. In the inactive state, a tight interdomain interface limits penetration of both PDZ-activating ligands...

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Share to Crystallography, X-Ray
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Secondary

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Source

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Identifiers

PMID: 27571206
DOI: 10.1371/journal.pone.0161526
PMCID: PMC5003398

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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