50 years of allosteric interactions: the twists and turns of the models.

doi:10.1038/nrm3695

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Article

50 years of allosteric interactions: the twists and turns of the models.

Nature reviews. Molecular cell biology - 1 Dec 2013

Changeux Jean-Pierre

Abstract excerpt

The concept of indirect or 'allosteric' interaction between topographically distinct sites, and the subsequent 1965 Monod-Wyman-Changeux (MWC) model for the conformational change mediating them, arose around 50 years ago. Many classic regulatory proteins (including haemoglobin, Asp transcarbamylase and nicotinic acetylcholine receptor) follow the central paradigm of the MWC model, which has been expanded and...

Topics

Allosteric Regulation
Allosteric Site
Animals
Catalytic Domain
Drug Design
Enzymes
Feedback, Physiological
Humans
Models, Biological
Models, Molecular
Mutation
Protein Structure, Quaternary

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Open in PubMed

Identifiers

PMID: 24150612
DOI: 10.1038/nrm3695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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