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Article

Role of conserved regulatory loop residues in allosteric propagation of serine protease HtrA2.

Biochemical and biophysical research communications - 26 Feb 2022

Parui Aasna L, Singh Nitu, Dutta Shubhankar, Bose Kakoli

Abstract excerpt

High temperature requirement protease A2 (HtrA2) is a mitochondrial serine protease that demonstrates multifaceted roles including protein quality control and proapoptotic properties in humans, making it a potential therapeutic target. Current literature suggests involvement of flexible regulatory loops in governing the allosteric propagation within the trimeric HtrA2 ensemble. Here, we have identified three...

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Identifiers

PMID: 35074587
DOI: 10.1016/j.bbrc.2022.01.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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