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Article

Intricate structural coordination and domain plasticity regulate activity of serine protease HtrA2.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2013

Chaganti Lalith K, Kuppili Raja Reddy, Bose Kakoli

Abstract excerpt

HtrA2, a complex trimeric pyramidal mitochondrial serine protease that regulates critical biological functions and diseases, including apoptosis and cancer, is a promising therapeutic target. It promotes apoptosis through multiple pathways, complex mechanisms of which are still elusive. The existing model of activation that emphasizes relative intramolecular movements between C-terminal PDZ and protease domains...

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Identifiers

PMID: 23608143
DOI: 10.1096/fj.13-227256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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