Article

S-Phase induced RNAs control ORC1 engagement to H2A.Z and firing of early DNA replication origins

2021-10-20

Abstract excerpt

<h4>Summary</h4> Coordinated initiation of DNA replication is essential to ensure efficient and timely DNA synthesis. Yet, the mechanism governing the “initiation” process in eukaryotic cells remains elusive. Here, we present data demonstrating a novel feature of RNAs transcribed in the proximity of actively replicating gene loci. We show that S-ph A se-RNAs a NC horing OR C1 (ANCOR s ) to the histone variant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f02f9ea7-cc12-5622-be54-757e36e07c62
DOI: 10.1101/2021.10.19.465050

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

S-Phase induced RNAs control ORC1 engagement to H2A.Z and firing of early DNA replication originsDOI 10.1101/2021.10.19.465050Read

RNAs anchoring replication complex control initiation and firing of DNA replicationSemantic proximity Read

ORC1 binds to <i>cis</i> -transcribed RNAs for efficient activation of replication originsSemantic proximity Read

Transcription drives DNA replication initiation and termination in human cellsSemantic proximity Read

Transcription shapes DNA replication initiation to preserve genome integritySemantic proximity Read

H3K37me1 couples transcription with DNA replication origin selectionSemantic proximity Read

Low replication stress leads to specific replication timing advances associated to chromatin remodelling in cancer cellsSemantic proximity Read

High Resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cellsSemantic proximity Read

Active transcription regulates ORC/MCM distribution whereas replication timing correlates with ORC density in human cellsSemantic proximity Read

Histone variant H2A.Z facilitates DNA replication.Semantic proximity Read

Regulation of replicative histone RNA metabolism by the histone chaperone ASF1Semantic proximity Read

Human <i>ribomes</i> reveal DNA-embedded ribonucleotides as a new type of epigenetic markSemantic proximity Read

Integrating process, proximity, and prediction implicates novel protein and RNA interactions in human Origin Recognition Complex functionSemantic proximity Read