Article

Regulation of replicative histone RNA metabolism by the histone chaperone ASF1

2022-11-30

Abstract excerpt

<h4>SUMMARY</h4> In S phase, duplication and assembly of the whole genome into chromatin requires upregulation of replicative histone gene expression. Here, we explored a potential role of histone chaperones in this process thereby linking chromatin assembly with histone production in human cells. Depletion of the ASF1 chaperone specifically decreased the pool of replicative histones both at the levels of soluble...

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Literature Corpus work: 1395cf31-90ec-5613-b46b-cc7fe825a419
DOI: 10.1101/2022.11.30.518476

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