Article

Human <i>ribomes</i> reveal DNA-embedded ribonucleotides as a new type of epigenetic mark

2025-06-30

Abstract excerpt

Ribonucleoside monophosphates (rNMPs) are abundant in DNA, but their distribution and function in human nuclear genomes remain unknown. Here, we mapped nearly one million rNMPs per genome across diverse human cell types, defining a nuclear “ ribome ” with non-random distribution patterns. rNMPs are enriched in C/G-rich sequences, epigenetically marked regions, and telomeres. Conserved ribonucleotide-enriched zone...

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Literature Corpus work: af93c3a0-717c-5950-b057-9a95c7b020b9
DOI: 10.1101/2025.06.27.661996

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