Article

DNA Double Strand Breaks cause chromosome loss through sister chromatid tethering in human embryos

2022-03-10

Abstract excerpt

<h4>Summary paragraph</h4> Genome editing by DNA double-strand breaks (DSB) is currently being investigated as a tool to treat or even prevent heritable diseases 1 . However, DNA repair mechanisms in the human embryo remain poorly understood and DSBs may result in chromosome loss 2,3 . Here we provide evidence of whole and segmental chromosome loss in over one third of chromosomes 16, 17 and X targeted by CRISP...

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Literature Corpus work: f01da725-d058-5096-a2b5-dac228f688b0
DOI: 10.1101/2022.03.10.483502

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