Article

Sperm DNA damage causes genomic instability in early embryonic development

2019-06-24

Abstract excerpt

Genomic instability is common in early embryo development, but the underlying causes are largely unknown. Here we examined the consequences of sperm DNA damage on the embryonic genome by single-cell genome sequencing of individual blastomeres from bovine embryos produced with sperm damaged by radiation. Sperm DNA damage caused fragmentation of chromosomes and segregation errors such as heterogoneic cell divisions...

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Literature Corpus work: dd3b7cea-0bae-5f9d-8197-75602e2f279f
DOI: 10.1101/681296

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