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Article

Aberrant chromosome morphology in human cells defective for Holliday junction resolution.

Nature - 31 Mar 2011

Wechsler Thomas, Newman Scott, West Stephen C

Abstract excerpt

In somatic cells, Holliday junctions can be formed between sister chromatids during the recombinational repair of DNA breaks or after replication fork demise. A variety of processes act upon Holliday junctions to remove them from DNA, in events that are critical for proper chromosome segregation. In human cells, the BLM protein, inactivated in individuals with Bloom's syndrome, acts in combination with...

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Share to Bloom Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21399624
DOI: 10.1038/nature09790
PMCID: PMC3560329

Genes

MUS81
SLX4
GEN1
BLM
EME1
RMI1
RMI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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