Article

Single-Cell Sequencing of Primate Preimplantation Embryos Reveals Chromosome Elimination Via Cellular Fragmentation and Blastomere Exclusion

2018-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Aneuploidy that arises during meiosis and/or mitosis is a major contributor to early embryo loss. We previously demonstrated that human preimplantation embryos encapsulate mis-segregated chromosomes into micronuclei while undergoing cellular fragmentation and that fragments can contain chromosomal material, but the source of this DNA was unknown. Here, we leveraged the use of a non-human primate...

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Literature Corpus work: 3d2ff1ef-b404-5a86-9b3c-36c21e71b0b3
DOI: 10.1101/241851

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