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Article

Chromosome instability is common in human cleavage-stage embryos.

Nature medicine - 1 May 2009

Vanneste Evelyne, Voet Thierry, Le Caignec Cédric, Ampe Michèle, Konings Peter, Melotte Cindy, Debrock Sophie, Amyere Mustapha, Vikkula Miikka, Schuit Frans, Fryns Jean-Pierre, Verbeke Geert, D'Hooghe Thomas, Moreau Yves, Vermeesch Joris R

Abstract excerpt

Chromosome instability is a hallmark of tumorigenesis. This study establishes that chromosome instability is also common during early human embryogenesis. A new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells. This revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent...

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Source

Identifiers

PMID: 19396175
DOI: 10.1038/nm.1924

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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