Article
Non-homologous end joining shapes the genomic rearrangement landscape of chromothripsis from mitotic errors
2023-08-11
Abstract excerpt
<h4>ABSTRACT</h4> Errors in mitosis can generate micronuclei that entrap mis-segregated chromosomes, which are susceptible to catastrophic fragmentation through a process termed chromothripsis. The reassembly of fragmented chromosomes by error-prone DNA double-strand break (DSB) repair generates a spectrum of simple and complex genomic rearrangements that are associated with human cancers and disorders. How speci...
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Identifiers and source
- Literature Corpus work
- 15c5aa0a-e343-5a55-96f7-bf02f50c5f99
- DOI
- 10.1101/2023.08.10.552800