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Sperm DNA damage causes genomic instability in early embryonic development

15 Apr 2020

Abstract excerpt

Genomic instability is common in human embryos, but the underlying causes are largely unknown. Here, we examined the consequences of sperm DNA damage on the embryonic genome by single-cell whole-genome sequencing of individual blastomeres from bovine embryos produced with sperm damaged by γ-radiation. Sperm DNA damage primarily leads to fragmentation of the paternal chromosomes followed by random distribution of...

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PMID: 32494621
DOI: 10.1126/sciadv.aaz7602

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