Article
Allele-Specific Chromosome Removal after Cas9 Cleavage in Human Embryos.
Cell - 10 Dec 2020
Zuccaro Michael V, Xu Jia, Mitchell Carl, Marin Diego, Zimmerman Raymond, Rana Bhavini, Weinstein Everett, King Rebeca T, Palmerola Katherine L, Smith Morgan E, Tsang Stephen H, Goland Robin, Jasin Maria, Lobo Rogerio, Treff Nathan, Egli Dieter
Abstract excerpt
Correction of disease-causing mutations in human embryos holds the potential to reduce the burden of inherited genetic disorders and improve fertility treatments for couples with disease-causing mutations in lieu of embryo selection. Here, we evaluate repair outcomes of a Cas9-induced double-strand break (DSB) introduced on the paternal chromosome at the EYS locus, which carries a frameshift mutation causing...
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