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Astrocyte cell-surface proteomics identified CD44 as an OPN/SPP1 receptor regulating lipid metabolism and glial crosstalk in Alzheimer’s disease

2025-12-09

Abstract excerpt

<h4>Abstract/Summary</h4> The development of β-amyloid (Aβ) pathology in Alzheimer’s disease (AD) is accompanied by profound changes in astrocytes and microglia. How these responses are orchestrated by cell surface proteins, key mediators of cell-cell communication, remain unclear. Using in situ astrocyte cell-surface proteome profiling in 5xFAD mice, we identified a set of dysregulated surface proteins induced b...

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Literature Corpus work
d9d5cf50-a957-5f86-912a-2bae8143fc20
DOI
10.64898/2025.12.05.692670
Open publication

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Astrocyte cell-surface proteomics identified CD44 as an OPN/SPP1 receptor regulating lipid metabolism and glial crosstalk in Alzheimer’s diseaseDOI 10.64898/2025.12.05.692670
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