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Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimer’s Disease Pathologies in Neurons

2025-12-14

Abstract excerpt

The two greatest risk factors for Alzheimer’s Disease (AD) are aging and Apolipoprotein E4 (APOE4) polymorphism, yet how these factors interact remain unclear. In this study, we investigate how bone morphogenetic protein (BMP) signaling, which increases with age, contributes to APOE4-induced lipid metabolic dysfunctions using induced-pluripotent stem cell (iPSC)-derived astrocytes and cocultured neurons. Surprisin...

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Literature Corpus work
5d4ebf79-ed94-58b8-b342-32cc558dcd9c
DOI
10.64898/2025.12.14.694212
Open publication

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Differential Regulation of APOE4-Mediated Astrocytic Lipid Metabolism by BMP Signaling Exacerbates Alzheimer’s Disease Pathologies in NeuronsDOI 10.64898/2025.12.14.694212
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