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APOE4 is a Risk Factor and Potential Therapeutic Target for Alzheimer's Disease

6 Mar 2023

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease, the main pathological hallmark of which is the loss of neurons, resulting in cognitive and memory impairments. Sporadic late-onset AD is a prevalent form of the disease and the apolipoprotein E4 (APOE4) genotype is the strongest predictor of the disease development. The structural variations of APOE isoforms affect their roles in synaptic...

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PMID: 36872358
DOI: 10.2174/1871527322666230303114425

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