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Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer's Disease.

Oxidative medicine and cellular longevity - 1 Jan 2020

Mamun Abdullah Al, Uddin Md Sahab, Bin Bashar Md Fahim, Zaman Sonia, Begum Yesmin, Bulbul Israt Jahan, Islam Md Siddiqul, Sarwar Md Shahid, Mathew Bijo, Amran Md Shah, Md Ashraf Ghulam, Bin-Jumah May N, Mousa Shaker A, Abdel-Daim Mohamed M

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disease that causes chronic cognitive dysfunction. Most of the AD cases are late onset, and the apolipoprotein E (APOE) isoform is a key genetic risk factor. The APOE gene has 3 key alleles in humans including APOE2, APOE3, and APOE4. Among them, APOE4 is the most potent genetic risk factor for late-onset AD (LOAD), while APOE2 has a defensive effect....

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Identifiers

PMID: 32509144
DOI: 10.1155/2020/5086250
PMCID: PMC7245681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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