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The multifaceted roles of apolipoprotein E4 in Alzheimer’s disease pathology and potential therapeutic strategies

8 Jul 2025

Abstract excerpt

Alzheimer's disease (AD), the most common dementia in the elderly, is marked by progressive cognitive decline and neurodegeneration. Core pathological hallmarks include amyloid-beta (Aβ) plaques, hyperphosphorylated tau aggregates, neuroinflammation, and metabolic dysfunction (e.g., impaired glucose utilization, mitochondrial deficits). Apolipoprotein E4 (ApoE4), the strongest genetic risk factor for AD,...

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PMID: 40628716
DOI: 10.1038/s41420-025-02600-y

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