Article

DNA methylation is indispensable for leukemia inhibitory factor dependent embryonic stem cells reprogramming

2020-03-18

Abstract excerpt

Naïve pluripotency can be maintained by the 2i/LIF supplements (CHIR99021, PD0325901 and LIF), which primarily affect canonical WNT, FGF/ERK, and JAK/STAT3 signaling. However, whether one of these tripartite supplements alone is sufficient to maintain naïve self-renewal remain unclear. Here we show that LIF alone is sufficient to induce reprogramming of 2i/LIF cultured ESCs (2i/L-ESCs) to ESCs with hypermethylated...

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Literature Corpus work: efbdae80-b658-5a4c-a03f-7bf1e0370ef5
DOI: 10.1101/2020.03.17.994939

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