Article

Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction Defects

2022-05-19

Abstract excerpt

<h4>ABSTRACT</h4> A complete knockout (KO) of a single key pluripotency gene has been shown to drastically affect embryonic stem cell (ESC) function and epigenetic reprogramming. However, knockin (KI)/KO of a reporter gene only in one of two alleles in a single pluripotency gene is considered harmless and is largely used in the stem cell field. Here, we sought to understand the impact of simultaneous elimination...

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Literature Corpus work: ef5c2b23-aa8d-5d8d-ad3a-daf5bbdb42a2
DOI: 10.1101/2022.05.18.492474

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Fibroblasts-derived from Pluripotent Cells Harboring a Single Allele Knockout in Two Pluripotency Genes Exhibit DNA Methylation Abnormalities and pluripotency induction DefectsDOI 10.1101/2022.05.18.492474Read

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