Article

Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature

2023-07-21

Abstract excerpt

Direct reprogramming is a technique for inducing the conversion of one type of somatic cell into another by the forced expression of defined transcription factors. Cell differentiation is generally determined by specific gene expression profiles based on distinct genome-wide epigenetic signatures. Although the CpG methylation of genomic DNA is an essential epigenetic factor that affects the transcriptional state o...

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Literature Corpus work: 02b76a0f-e8b7-50af-b1be-2f9bea4627b9
DOI: 10.1101/2023.07.21.549976

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