Article

Capture of mouse and human stem cells with features of formative pluripotency

2020-09-04

Abstract excerpt

<h4>SUMMARY</h4> Pluripotent cells emerge via a naïve founder population in the blastocyst, acquire capacity for germline and soma formation, and then undergo lineage priming. Mouse embryonic stem (ES) cells and epiblast stem cells (EpiSCs) represent the initial naïve and final primed phases of pluripotency, respectively. Here we investigate the intermediate formative stage. Using minimal exposure to specificatio...

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Literature Corpus work: 4a10b26b-411c-5a83-b5bb-e727afffc705
DOI: 10.1101/2020.09.04.283218

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