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Article

Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal.

Stem cell reports - 11 Aug 2015

Papatsenko Dmitri, Darr Henia, Kulakovskiy Ivan V, Waghray Avinash, Makeev Vsevolod J, MacArthur Ben D, Lemischka Ihor R

Abstract excerpt

Analyses of gene expression in single mouse embryonic stem cells (mESCs) cultured in serum and LIF revealed the presence of two distinct cell subpopulations with individual gene expression signatures. Comparisons with published data revealed that cells in the first subpopulation are phenotypically similar to cells isolated from the inner cell mass (ICM). In contrast, cells in the second subpopulation appear to be...

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Identifiers

PMID: 26267829
DOI: 10.1016/j.stemcr.2015.07.004
PMCID: PMC4618835

Genes

LIF
NANOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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