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Article

Intracellular Signaling Pathways Regulating Pluripotency of Embryonic Stem Cells

1 Jan 2006

Abstract excerpt

The cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is also well-documented. However, LIF is not involved in self-renewal of human ES cells, suggesting that other pathways must play an important role in this process. The importance of other signal transduction pathways,...

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PMID: 18220859
DOI: 10.2174/157488806775269061

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