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Article

Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming by Epigenetic Regulation

12 Sept 2012

Abstract excerpt

Although leukemia inhibitory factor (LIF) maintains the ground state pluripotency of mouse embryonic stem cells and induced pluripotent stem cells (iPSCs) by activating the Janus kinase/signal transducer and activator of transcription 3 (Jak/Stat3) pathway, the mechanism remained unclear. Stat3 has only been shown to promote complete reprogramming of epiblast and neural stem cells and partially reprogrammed cells...

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PMID: 22968989
DOI: 10.1002/stem.1225

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