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Article

Delayed differentiation in embryonic stem cells and mesodermal progenitors in the absence of CtBP2.

Mechanisms of development - 1 Jan 2000

Tarleton Heather P, Lemischka Ihor R

Abstract excerpt

Mammalian embryonic stem cells (ESCs) are characterized by an ability to self-renew and give rise to each of the three germ layers. ESCs are a pluripotential source of numerous primitive progenitors and committed lineages and can make stoichiometric decisions leading to either asymmetric or symmetric cell division. Several genes have been identified as essential for maintenance of self-renewal, but few...

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PMID: 19825414
DOI: 10.1016/j.mod.2009.10.002
PMCID: PMC2818266

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