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Article

Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals.

eLife - 11 Dec 2024

Kainov Yaroslav, Hamid Fursham, Makeyev Eugene V

Abstract excerpt

The expression of eukaryotic genes relies on the precise 3'-terminal cleavage and polyadenylation of newly synthesized pre-mRNA transcripts. Defects in these processes have been associated with various diseases, including cancer. While cancer-focused sequencing studies have identified numerous driver mutations in protein-coding sequences, noncoding drivers - particularly those affecting the cis-elements required...

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Identifiers

PMID: 39660592
DOI: 10.7554/eLife.99040
PMCID: PMC11634062

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