Article
Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals
2024-06-28
Abstract excerpt
The expression of eukaryotic genes relies on the precise 3’-terminal cleavage and polyadenylation of newly synthesized pre-mRNA transcripts. Defects in these processes have been associated with various diseases, including cancer. While cancer-focused sequencing studies have identified numerous driver mutations in protein-coding sequences, noncoding drivers – particularly those affecting the cis-elements required f...
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Identifiers and source
- Literature Corpus work
- 60d45ebc-75bd-574d-a2ea-896efa3c8890
- DOI
- 10.1101/2024.06.23.600297